Is Sativex effective for neuropathic pain?

Sativex(R) – also called nabiximols – is a pharmaceutical mouth spray containing the plant-derived cannabis compounds THC and CBD in equal amounts per spray (2.5mg THC, 2.7mg CBD) in an alcohol solution with mint flavour. It is approved in Canada as adjunctive treatment for spasticity in adult patients with multiple sclerosis who have not responded to routine care. While there is some potential for cannabinoid products to treat neuropathic pain, the data is not strong enough to make firm recommendations. While Health Canada suggests that health professionals consider options other than Sativex for neuopathic pain, current guidance suggests that orally administered cannabinoids may be considered if standard chronic pain treatment is not effective or not tolerated, in patients who do not have important risk factors (including but not limited to pregnancy, breastfeeding, heart disease, psychosis. major mental health concerns. Please speak to your health care professional to discuss whether cannabinoids may be safe to consider.