Mohamed Chahine - Quebec Pain Research Network
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Mohamed Chahine

Ph.D. (doctor),  Regular member
Principal Interest
Pain genetics
Secondary Interest
Neuropathic pain
Primary Affiliation

Université Laval

Secondary Affiliation
Centre de recherche CERVO (CERVO)

Subscription date
22 April 2020

Biography

Ion channels play an important role in cell excitability, extending from the transmission of influx in neurons to the initiation of striated muscle contraction and hormone secretion. Mohamed Chahine’s research deals with structure-function studies on voltage gated sodium channels and their implication in several human diseases known as sodium "channelopathies" including congenital pain disorder.
In his laboratory he developed an expertise to study the biochemistry of the channels via its structure-function relationship which will permits an understanding of which parts of the channel are involved in various channel states, sites of drug and toxin binding, and the topological arrangement of the channel in the membrane. He also initiated several studies aimed at understanding the molecular mechanisms of local anaesthetics action.