The Effect of Widespread Pain on Knee Pain Worsening, Incident Knee Osteoarthritis (OA), and Incident Knee Pain: The Multicenter OA (MOST) Study.

TitleThe Effect of Widespread Pain on Knee Pain Worsening, Incident Knee Osteoarthritis (OA), and Incident Knee Pain: The Multicenter OA (MOST) Study.
Publication TypeJournal Article
Year of Publication2017
AuthorsCarlesso LC, Niu J, Segal NA, Frey-Law LA, Lewis CE, Nevitt MC, Neogi T
JournalJ Rheumatol
Date Published2017 Mar 01
ISSN0315-162X
Abstract

OBJECTIVE: Whether widespread pain (WSP) affects the risk of developing knee pain or knee osteoarthritis (OA) is unknown and could enhance understanding of pain mechanisms in OA.METHODS: Subjects from the Multicenter OA (MOST) study, a US National Institutes of Health-funded prospective cohort of older adults with or at risk of knee OA, were characterized regarding WSP, defined as pain above and below the waist on both sides of the body and axially using a standard homunculus, excluding knee pain at 60 months (baseline). Followup occurred 2 years later. We assessed the relation of WSP to odds of knee pain worsening (≥ 2-point increase in the Western Ontario and McMaster Universities Arthritis Index pain subscale) using logistic regression, and to odds of incident radiographic knee OA (ROA; Kellgren-Lawrence arthritis scale ≥ grade 2 of either knee among those free of ROA at baseline) and incident consistent frequent knee pain (CFKP; knee pain on most days during the past month among participants free of knee pain at baseline) in 1 or both knees using multinomial regression adjusting for potential confounders.RESULTS: There were 1752 participants available for analysis [mean age (SD) 67.0 yrs (7.7), body mass index 30.5 kg/m(2) (5.9), 59% women]. Baseline presence of WSP was not associated with worsened knee pain (adjusted OR 1.15, 95% CI 0.89-1.48, p = 0.30), ROA (adjusted OR 0.86, 95% CI 0.46-1.63, p = 0.65), or incident CFKP (adjusted OR 1.69, 95% CI 0.96-2.96, p = 0.07).CONCLUSION: WSP was not significantly associated with worsening knee pain, incident ROA, or CFKP. Development of knee pain and ROA does not appear to be influenced by underlying WSP.

DOI10.3899/jrheum.160853
Alternate JournalJ. Rheumatol.
PubMed ID28250143
Grant ListR01 AR062506 / AR / NIAMS NIH HHS / United States
U01 AG018947 / AG / NIA NIH HHS / United States
U01 AG019069 / AG / NIA NIH HHS / United States
U01 AG018820 / AG / NIA NIH HHS / United States
P60 AR047785 / AR / NIAMS NIH HHS / United States
U01 AG018832 / AG / NIA NIH HHS / United States